Parkinson's disease-related LRRK2 G2019S mutation results from independent mutational events in humans
Identifieur interne : 000445 ( Main/Exploration ); précédent : 000444; suivant : 000446Parkinson's disease-related LRRK2 G2019S mutation results from independent mutational events in humans
Auteurs : Suzanne Lesage ; Etienne Patin ; Christel Condroyer ; Anne-Louise Leutenegger ; Ebba Lohmann ; Nir Giladi ; Anat Bar-Shira ; Soraya Belarbi ; Nassima Hecham ; Pierre Pollak [Suisse] ; Anne-Marie Ouvrard-Hernandez ; Soraya Bardien ; Jonathan Carr ; Traki Benhassine ; Hiroyuki Tomiyama ; Caroline Pirkevi ; Tarik Hamadouche ; Ccile Cazeneuve [France] ; A. Nazli Basak ; Nobutaka Hattori ; Alexandra Drr [France] ; Meriem Tazir ; Avi Orr-Urtreger ; Lluis Quintana-Murci ; Alexis Brice [France] ; Yves Agid [France] ; A.-M. Bonnet ; M. Borg ; A. Brice ; E. Broussolle ; Ph. Damier ; A. Deste ; A. Drr ; F. Durif ; E. Lohmann ; M. Martinez ; C. Penet ; Pierre Pollak [Suisse] ; Olivier Rascol [France] ; F. Tison ; C. Tranchant ; A. Troiano ; M. Vrin ; F. Viallet ; M. VidailhetSource :
- Human Molecular Genetics [ 0964-6906 ] ; 2010-05-15.
Abstract
Mutations in the leucine-rich-repeat kinase 2 (LRRK2) gene have been identified in families with autosomal dominant Parkinson's disease (PD) and in sporadic cases; the G2019S mutation is the single most frequent. Intriguingly, the frequency of this mutation in PD patients varies greatly among ethnic groups and geographic origins: it is present at <0.1 in East Asia, 2 in European-descent patients and can reach frequencies of up to 1540 in PD Ashkenazi Jews and North African Arabs. To ascertain the evolutionary dynamics of the G2019S mutation in different populations, we genotyped 74 markers spanning a 16 Mb genomic region around G2019S, in 191 individuals carrying the mutation from 126 families of different origins. Sixty-seven families were of North-African Arab origin, 18 were of North/Western European descent, 37 were of Jewish origin, mostly from Eastern Europe, one was from Japan, one from Turkey and two were of mixed origins. We found the G2019S mutation on three different haplotypes. Network analyses of the three carrier haplotypes showed that G2019S arose independently at least twice in humans. In addition, the population distribution of the intra-allelic diversity of the most widespread carrier haplotype, together with estimations of the age of G2019S determined by two different methods, suggests that one of the founding G2019S mutational events occurred in the Near East at least 4000 years ago.
Url:
DOI: 10.1093/hmg/ddq081
Affiliations:
- France, Suisse
- Canton de Genève, Midi-Pyrénées, Île-de-France
- Genève, Paris, Toulouse
- Hôpital de la Salpêtrière, Hôpitaux universitaires de Genève, Université Toulouse III - Paul Sabatier, Université de Toulouse
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Nazli" last="Basak">A. Nazli Basak</name></author><author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name></author><author><name sortKey="Drr, Alexandra" sort="Drr, Alexandra" uniqKey="Drr A" first="Alexandra" last="Drr">Alexandra Drr</name></author><author><name sortKey="Tazir, Meriem" sort="Tazir, Meriem" uniqKey="Tazir M" first="Meriem" last="Tazir">Meriem Tazir</name></author><author><name sortKey="Orr Urtreger, Avi" sort="Orr Urtreger, Avi" uniqKey="Orr Urtreger A" first="Avi" last="Orr-Urtreger">Avi Orr-Urtreger</name></author><author><name sortKey="Quintana Murci, Lluis" sort="Quintana Murci, Lluis" uniqKey="Quintana Murci L" first="Lluis" last="Quintana-Murci">Lluis Quintana-Murci</name></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name></author><author wicri:is="80%"><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author wicri:is="80%"><name sortKey="Bonnet, A M" sort="Bonnet, A M" uniqKey="Bonnet A" first="A.-M." last="Bonnet">A.-M. Bonnet</name></author><author wicri:is="80%"><name sortKey="Borg, M" sort="Borg, M" uniqKey="Borg M" first="M." last="Borg">M. Borg</name></author><author wicri:is="80%"><name sortKey="Brice, A" sort="Brice, A" uniqKey="Brice A" first="A." last="Brice">A. Brice</name></author><author wicri:is="80%"><name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E." last="Broussolle">E. Broussolle</name></author><author wicri:is="80%"><name sortKey="Damier, Ph" sort="Damier, Ph" uniqKey="Damier P" first="Ph." last="Damier">Ph. Damier</name></author><author wicri:is="80%"><name sortKey="Deste, A" sort="Deste, A" uniqKey="Deste A" first="A." last="Deste">A. Deste</name></author><author wicri:is="80%"><name sortKey="Drr, A" sort="Drr, A" uniqKey="Drr A" first="A." last="Drr">A. Drr</name></author><author wicri:is="80%"><name sortKey="Durif, F" sort="Durif, F" uniqKey="Durif F" first="F." last="Durif">F. 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Vidailhet</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:CE0CB88A3A306621CA16D7701243C098C3883248</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1093/hmg/ddq081</idno><idno type="url">https://api.istex.fr/document/CE0CB88A3A306621CA16D7701243C098C3883248/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000399</idno><idno type="wicri:Area/Main/Curation">000345</idno><idno type="wicri:Area/Main/Exploration">000445</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Parkinson's disease-related LRRK2 G2019S mutation results from independent mutational events in humans</title><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Patin, Etienne" sort="Patin, Etienne" uniqKey="Patin E" first="Etienne" last="Patin">Etienne Patin</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Condroyer, Christel" sort="Condroyer, Christel" uniqKey="Condroyer C" first="Christel" last="Condroyer">Christel Condroyer</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Leutenegger, Anne Louise" sort="Leutenegger, Anne Louise" uniqKey="Leutenegger A" first="Anne-Louise" last="Leutenegger">Anne-Louise Leutenegger</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Lohmann, Ebba" sort="Lohmann, Ebba" uniqKey="Lohmann E" first="Ebba" last="Lohmann">Ebba Lohmann</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name><affiliation><wicri:noCountry code="no comma">Movement Disorders Unit Parkinson Center Department of Neurology and</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Bar Shira, Anat" sort="Bar Shira, Anat" uniqKey="Bar Shira A" first="Anat" last="Bar-Shira">Anat Bar-Shira</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Belarbi, Soraya" sort="Belarbi, Soraya" uniqKey="Belarbi S" first="Soraya" last="Belarbi">Soraya Belarbi</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Hecham, Nassima" sort="Hecham, Nassima" uniqKey="Hecham N" first="Nassima" last="Hecham">Nassima Hecham</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry><country>Suisse</country><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName><orgName>Hôpitaux universitaires de Genève</orgName></affiliation></author><author><name sortKey="Ouvrard Hernandez, Anne Marie" sort="Ouvrard Hernandez, Anne Marie" uniqKey="Ouvrard Hernandez A" first="Anne-Marie" last="Ouvrard-Hernandez">Anne-Marie Ouvrard-Hernandez</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Bardien, Soraya" sort="Bardien, Soraya" uniqKey="Bardien S" first="Soraya" last="Bardien">Soraya Bardien</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Carr, Jonathan" sort="Carr, Jonathan" uniqKey="Carr J" first="Jonathan" last="Carr">Jonathan Carr</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Benhassine, Traki" sort="Benhassine, Traki" uniqKey="Benhassine T" first="Traki" last="Benhassine">Traki Benhassine</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Tomiyama, Hiroyuki" sort="Tomiyama, Hiroyuki" uniqKey="Tomiyama H" first="Hiroyuki" last="Tomiyama">Hiroyuki Tomiyama</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Pirkevi, Caroline" sort="Pirkevi, Caroline" uniqKey="Pirkevi C" first="Caroline" last="Pirkevi">Caroline Pirkevi</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Hamadouche, Tarik" sort="Hamadouche, Tarik" uniqKey="Hamadouche T" first="Tarik" last="Hamadouche">Tarik Hamadouche</name><affiliation><wicri:noCountry code="subField">Algeria and</wicri:noCountry></affiliation></author><author><name sortKey="Cazeneuve, Ccile" sort="Cazeneuve, Ccile" uniqKey="Cazeneuve C" first="Ccile" last="Cazeneuve">Ccile Cazeneuve</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Genetics and Cytogenetics, AP-HP, Piti-Salptrire Hospital, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Basak, A Nazli" sort="Basak, A Nazli" uniqKey="Basak A" first="A. Nazli" last="Basak">A. Nazli Basak</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Drr, Alexandra" sort="Drr, Alexandra" uniqKey="Drr A" first="Alexandra" last="Drr">Alexandra Drr</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Genetics and Cytogenetics, AP-HP, Piti-Salptrire Hospital, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tazir, Meriem" sort="Tazir, Meriem" uniqKey="Tazir M" first="Meriem" last="Tazir">Meriem Tazir</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Orr Urtreger, Avi" sort="Orr Urtreger, Avi" uniqKey="Orr Urtreger A" first="Avi" last="Orr-Urtreger">Avi Orr-Urtreger</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Quintana Murci, Lluis" sort="Quintana Murci, Lluis" uniqKey="Quintana Murci L" first="Lluis" last="Quintana-Murci">Lluis Quintana-Murci</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Genetics and Cytogenetics, AP-HP, Piti-Salptrire Hospital, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation></author><author wicri:is="80%"><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author wicri:is="80%"><name sortKey="Bonnet, A M" sort="Bonnet, A M" uniqKey="Bonnet A" first="A.-M." last="Bonnet">A.-M. Bonnet</name></author><author wicri:is="80%"><name sortKey="Borg, M" sort="Borg, M" uniqKey="Borg M" first="M." last="Borg">M. Borg</name></author><author wicri:is="80%"><name sortKey="Brice, A" sort="Brice, A" uniqKey="Brice A" first="A." last="Brice">A. Brice</name></author><author wicri:is="80%"><name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E." last="Broussolle">E. Broussolle</name></author><author wicri:is="80%"><name sortKey="Damier, Ph" sort="Damier, Ph" uniqKey="Damier P" first="Ph." last="Damier">Ph. Damier</name></author><author wicri:is="80%"><name sortKey="Deste, A" sort="Deste, A" uniqKey="Deste A" first="A." last="Deste">A. Deste</name></author><author wicri:is="80%"><name sortKey="Drr, A" sort="Drr, A" uniqKey="Drr A" first="A." last="Drr">A. Drr</name></author><author wicri:is="80%"><name sortKey="Durif, F" sort="Durif, F" uniqKey="Durif F" first="F." last="Durif">F. Durif</name></author><author wicri:is="80%"><name sortKey="Lohmann, E" sort="Lohmann, E" uniqKey="Lohmann E" first="E." last="Lohmann">E. Lohmann</name></author><author wicri:is="80%"><name sortKey="Martinez, M" sort="Martinez, M" uniqKey="Martinez M" first="M." last="Martinez">M. Martinez</name></author><author wicri:is="80%"><name sortKey="Penet, C" sort="Penet, C" uniqKey="Penet C" first="C." last="Penet">C. Penet</name></author><author wicri:is="80%"><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P." last="Pollak">Pierre Pollak</name><affiliation><country>Suisse</country><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName><orgName>Hôpitaux universitaires de Genève</orgName></affiliation></author><author wicri:is="80%"><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O." last="Rascol">Olivier Rascol</name><affiliation><country>France</country><placeName><settlement type="city">Toulouse</settlement><region type="region" nuts="2">Midi-Pyrénées</region></placeName><orgName type="university" n="3">Université Toulouse III - Paul Sabatier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Toulouse</orgName></affiliation></author><author wicri:is="80%"><name sortKey="Tison, F" sort="Tison, F" uniqKey="Tison F" first="F." last="Tison">F. Tison</name></author><author wicri:is="80%"><name sortKey="Tranchant, C" sort="Tranchant, C" uniqKey="Tranchant C" first="C." last="Tranchant">C. Tranchant</name></author><author wicri:is="80%"><name sortKey="Troiano, A" sort="Troiano, A" uniqKey="Troiano A" first="A." last="Troiano">A. Troiano</name></author><author wicri:is="80%"><name sortKey="Vrin, M" sort="Vrin, M" uniqKey="Vrin M" first="M." last="Vrin">M. Vrin</name></author><author wicri:is="80%"><name sortKey="Viallet, F" sort="Viallet, F" uniqKey="Viallet F" first="F." last="Viallet">F. Viallet</name></author><author wicri:is="80%"><name sortKey="Vidailhet, M" sort="Vidailhet, M" uniqKey="Vidailhet M" first="M." last="Vidailhet">M. Vidailhet</name></author></analytic><monogr></monogr><series><title level="j">Human Molecular Genetics</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2010-05-15">2010-05-15</date><biblScope unit="volume">19</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1998">1998</biblScope><biblScope unit="page" to="2004">2004</biblScope></imprint><idno type="ISSN">0964-6906</idno></series><idno type="istex">CE0CB88A3A306621CA16D7701243C098C3883248</idno><idno type="DOI">10.1093/hmg/ddq081</idno><idno type="ArticleID">ddq081</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0964-6906</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Mutations in the leucine-rich-repeat kinase 2 (LRRK2) gene have been identified in families with autosomal dominant Parkinson's disease (PD) and in sporadic cases; the G2019S mutation is the single most frequent. Intriguingly, the frequency of this mutation in PD patients varies greatly among ethnic groups and geographic origins: it is present at <0.1 in East Asia, 2 in European-descent patients and can reach frequencies of up to 1540 in PD Ashkenazi Jews and North African Arabs. To ascertain the evolutionary dynamics of the G2019S mutation in different populations, we genotyped 74 markers spanning a 16 Mb genomic region around G2019S, in 191 individuals carrying the mutation from 126 families of different origins. Sixty-seven families were of North-African Arab origin, 18 were of North/Western European descent, 37 were of Jewish origin, mostly from Eastern Europe, one was from Japan, one from Turkey and two were of mixed origins. We found the G2019S mutation on three different haplotypes. Network analyses of the three carrier haplotypes showed that G2019S arose independently at least twice in humans. In addition, the population distribution of the intra-allelic diversity of the most widespread carrier haplotype, together with estimations of the age of G2019S determined by two different methods, suggests that one of the founding G2019S mutational events occurred in the Near East at least 4000 years ago.</div></front></TEI><affiliations><list><country><li>France</li><li>Suisse</li></country><region><li>Canton de Genève</li><li>Midi-Pyrénées</li><li>Île-de-France</li></region><settlement><li>Genève</li><li>Paris</li><li>Toulouse</li></settlement><orgName><li>Hôpital de la Salpêtrière</li><li>Hôpitaux universitaires de Genève</li><li>Université Toulouse III - Paul Sabatier</li><li>Université de Toulouse</li></orgName></list><tree><noCountry><name sortKey="Bar Shira, Anat" sort="Bar Shira, Anat" uniqKey="Bar Shira A" first="Anat" last="Bar-Shira">Anat Bar-Shira</name><name sortKey="Bardien, Soraya" sort="Bardien, Soraya" uniqKey="Bardien S" first="Soraya" last="Bardien">Soraya Bardien</name><name sortKey="Basak, A Nazli" sort="Basak, A Nazli" uniqKey="Basak A" first="A. Nazli" last="Basak">A. Nazli Basak</name><name sortKey="Belarbi, Soraya" sort="Belarbi, Soraya" uniqKey="Belarbi S" first="Soraya" last="Belarbi">Soraya Belarbi</name><name sortKey="Benhassine, Traki" sort="Benhassine, Traki" uniqKey="Benhassine T" first="Traki" last="Benhassine">Traki Benhassine</name><name sortKey="Bonnet, A M" sort="Bonnet, A M" uniqKey="Bonnet A" first="A.-M." last="Bonnet">A.-M. Bonnet</name><name sortKey="Borg, M" sort="Borg, M" uniqKey="Borg M" first="M." last="Borg">M. Borg</name><name sortKey="Brice, A" sort="Brice, A" uniqKey="Brice A" first="A." last="Brice">A. Brice</name><name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E." last="Broussolle">E. Broussolle</name><name sortKey="Carr, Jonathan" sort="Carr, Jonathan" uniqKey="Carr J" first="Jonathan" last="Carr">Jonathan Carr</name><name sortKey="Condroyer, Christel" sort="Condroyer, Christel" uniqKey="Condroyer C" first="Christel" last="Condroyer">Christel Condroyer</name><name sortKey="Damier, Ph" sort="Damier, Ph" uniqKey="Damier P" first="Ph." last="Damier">Ph. Damier</name><name sortKey="Deste, A" sort="Deste, A" uniqKey="Deste A" first="A." last="Deste">A. Deste</name><name sortKey="Drr, A" sort="Drr, A" uniqKey="Drr A" first="A." last="Drr">A. Drr</name><name sortKey="Durif, F" sort="Durif, F" uniqKey="Durif F" first="F." last="Durif">F. Durif</name><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name><name sortKey="Hamadouche, Tarik" sort="Hamadouche, Tarik" uniqKey="Hamadouche T" first="Tarik" last="Hamadouche">Tarik Hamadouche</name><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><name sortKey="Hecham, Nassima" sort="Hecham, Nassima" uniqKey="Hecham N" first="Nassima" last="Hecham">Nassima Hecham</name><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><name sortKey="Leutenegger, Anne Louise" sort="Leutenegger, Anne Louise" uniqKey="Leutenegger A" first="Anne-Louise" last="Leutenegger">Anne-Louise Leutenegger</name><name sortKey="Lohmann, E" sort="Lohmann, E" uniqKey="Lohmann E" first="E." last="Lohmann">E. Lohmann</name><name sortKey="Lohmann, Ebba" sort="Lohmann, Ebba" uniqKey="Lohmann E" first="Ebba" last="Lohmann">Ebba Lohmann</name><name sortKey="Martinez, M" sort="Martinez, M" uniqKey="Martinez M" first="M." last="Martinez">M. Martinez</name><name sortKey="Orr Urtreger, Avi" sort="Orr Urtreger, Avi" uniqKey="Orr Urtreger A" first="Avi" last="Orr-Urtreger">Avi Orr-Urtreger</name><name sortKey="Ouvrard Hernandez, Anne Marie" sort="Ouvrard Hernandez, Anne Marie" uniqKey="Ouvrard Hernandez A" first="Anne-Marie" last="Ouvrard-Hernandez">Anne-Marie Ouvrard-Hernandez</name><name sortKey="Patin, Etienne" sort="Patin, Etienne" uniqKey="Patin E" first="Etienne" last="Patin">Etienne Patin</name><name sortKey="Penet, C" sort="Penet, C" uniqKey="Penet C" first="C." last="Penet">C. Penet</name><name sortKey="Pirkevi, Caroline" sort="Pirkevi, Caroline" uniqKey="Pirkevi C" first="Caroline" last="Pirkevi">Caroline Pirkevi</name><name sortKey="Quintana Murci, Lluis" sort="Quintana Murci, Lluis" uniqKey="Quintana Murci L" first="Lluis" last="Quintana-Murci">Lluis Quintana-Murci</name><name sortKey="Tazir, Meriem" sort="Tazir, Meriem" uniqKey="Tazir M" first="Meriem" last="Tazir">Meriem Tazir</name><name sortKey="Tison, F" sort="Tison, F" uniqKey="Tison F" first="F." last="Tison">F. Tison</name><name sortKey="Tomiyama, Hiroyuki" sort="Tomiyama, Hiroyuki" uniqKey="Tomiyama H" first="Hiroyuki" last="Tomiyama">Hiroyuki Tomiyama</name><name sortKey="Tranchant, C" sort="Tranchant, C" uniqKey="Tranchant C" first="C." last="Tranchant">C. Tranchant</name><name sortKey="Troiano, A" sort="Troiano, A" uniqKey="Troiano A" first="A." last="Troiano">A. Troiano</name><name sortKey="Viallet, F" sort="Viallet, F" uniqKey="Viallet F" first="F." last="Viallet">F. Viallet</name><name sortKey="Vidailhet, M" sort="Vidailhet, M" uniqKey="Vidailhet M" first="M." last="Vidailhet">M. Vidailhet</name><name sortKey="Vrin, M" sort="Vrin, M" uniqKey="Vrin M" first="M." last="Vrin">M. Vrin</name></noCountry><country name="Suisse"><region name="Canton de Genève"><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name></region><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P." last="Pollak">Pierre Pollak</name></country><country name="France"><noRegion><name sortKey="Cazeneuve, Ccile" sort="Cazeneuve, Ccile" uniqKey="Cazeneuve C" first="Ccile" last="Cazeneuve">Ccile Cazeneuve</name></noRegion><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Drr, Alexandra" sort="Drr, Alexandra" uniqKey="Drr A" first="Alexandra" last="Drr">Alexandra Drr</name><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O." last="Rascol">Olivier Rascol</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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